Hereditary Haemochromatosis (HFE): Causes, Symptoms, Diagnosis & Treatment

Hereditary Haemochromatosis (HFE): Causes, Symptoms, Diagnosis, and Treatment Complete article to Iron Overload Disorder | Symptoms, Genetics, Testing, and Management Hereditary Haemochromatosis (HFE) is one of the most common genetic disorders affecting iron metabolism in the human body. Despite its prevalence, it remains widely underdiagnosed due to its slow progression and non-specific early symptoms. This condition leads to excessive absorption and accumulation of iron in vital organs such as the liver, heart, pancreas, joints, and skin. Over time, this excess iron can cause serious and potentially life-threatening complications. In this comprehensive article, we will explore what Hereditary Haemochromatosis is, how it develops, its genetic basis, symptoms, diagnostic methods, treatment options, lifestyle modifications, and long-term outlook. This article is designed to be informative, easy to understand, and valuable for patients, caregivers, medical students, and hea...

Irregular Periods & Fertility: Causes & Treatment | Sanovra Lab

Irregular Periods: Causes, Symptoms, Diagnosis, Treatment & Lifestyle

Irregular periods are one of the most common yet misunderstood health concerns among women. Many women experience changes in their menstrual cycle at some point in life, but when periods become unpredictable, delayed, too frequent, very heavy, or completely absent, it may signal an underlying health issue that should not be ignored.

The menstrual cycle is closely connected to hormonal balance, metabolism, stress levels, nutrition, and overall reproductive health. Any disturbance in these systems can directly affect the regularity of periods. While occasional delays may be harmless, persistent irregular periods require proper medical evaluation.

What Are Irregular Periods?

A normal menstrual cycle usually ranges between 21 to 35 days, with bleeding lasting 3 to 7 days. However, not every woman has a textbook cycle. What matters most is consistency.

Periods are considered irregular when:

  • The cycle length changes significantly every month
  • Periods occur too frequently or too infrequently
  • Bleeding is extremely heavy or unusually light
  • Periods stop for several months without pregnancy

Irregular periods may appear as early periods, delayed periods, missed periods, spotting between cycles, or prolonged bleeding.

Why Do Periods Become Irregular?

The menstrual cycle is controlled by a delicate interaction between the brain, ovaries, thyroid gland, adrenal glands, and uterus. Any disruption in this hormonal communication can affect cycle regularity.

Hormonal Causes of Irregular Periods

Polycystic Ovary Syndrome (PCOS)

PCOS is one of the leading causes of irregular periods in women of reproductive age. In this condition, ovulation does not occur regularly due to hormonal imbalance, especially increased male hormones (androgens).

When ovulation does not happen, progesterone is not produced adequately, which results in delayed or missed periods. Over time, this may also lead to heavy and unpredictable bleeding.

Common signs of PCOS include:

  • Irregular or absent periods
  • Weight gain or difficulty losing weight
  • Acne and oily skin
  • Excess hair growth on face, chest, or abdomen

Thyroid Disorders

The thyroid gland plays an important role in regulating metabolism and reproductive hormones. Both hypothyroidism (low thyroid) and hyperthyroidism (high thyroid) can disturb menstrual cycles.

Low thyroid levels often cause delayed or heavy periods, while high thyroid levels may lead to very light or absent periods.

High Prolactin Levels

Prolactin is a hormone responsible for breast milk production. When prolactin levels are abnormally high, ovulation may stop, leading to missed or irregular periods.

Lifestyle and Stress-Related Causes

Chronic Stress

Stress increases cortisol levels, which directly suppress reproductive hormones. Long-term stress can completely shut down ovulation, resulting in missed periods.

Sudden Weight Changes

Rapid weight loss or gain affects estrogen production. Low body fat can stop periods, while excess weight increases estrogen levels, leading to irregular or heavy bleeding.

Excessive Exercise

Intense physical training without adequate nutrition may cause exercise-induced amenorrhea, especially in athletes.

Symptoms That Often Accompany Irregular Periods

  • Heavy menstrual bleeding
  • Spotting between periods
  • Severe abdominal or pelvic pain
  • Fatigue and weakness
  • Hair fall and skin problems
  • Difficulty in conceiving

How Are Irregular Periods Diagnosed?

Diagnosis begins with understanding your menstrual history, lifestyle habits, and associated symptoms. Doctors may recommend the following tests:

  • Pregnancy test
  • Thyroid function test (TSH)
  • FSH and LH hormone tests
  • Prolactin levels
  • Pelvic ultrasound

These tests help identify hormonal imbalance, ovarian disorders, or structural problems of the uterus.

Treatment Options for Irregular Periods

Treatment depends on the underlying cause, age, and whether the woman is planning pregnancy.

Lifestyle Modification

  • Balanced diet rich in fiber and protein
  • Maintaining a healthy body weight
  • Regular moderate exercise
  • Stress management and proper sleep

Medical Treatment

Doctors may prescribe hormonal therapy, thyroid medication, or medicines to improve insulin sensitivity depending on the diagnosis. Iron supplements may be given if anemia is present.

Irregular Periods and Fertility

Irregular periods often indicate irregular ovulation, which can make it difficult to conceive naturally. However, many women successfully conceive once the root cause is treated.

Early diagnosis and treatment play a key role in preserving fertility and preventing long-term complications.

When Should You See a Doctor?

  • Periods absent for more than 3 months
  • Bleeding lasting more than 7–10 days
  • Very heavy bleeding causing weakness
  • Severe pain during periods
  • Irregular periods with infertility

Conclusion

Irregular periods are not merely a menstrual inconvenience; they are an important indicator of overall hormonal and reproductive health. Ignoring them may lead to complications such as anemia, infertility, or endometrial problems.

With timely diagnosis, healthy lifestyle changes, and appropriate medical treatment, most women can restore a regular menstrual cycle and improve their quality of life.

⚠️ Medical Disclaimer: This article is intended for educational and informational purposes only. It does not replace professional medical advice, diagnosis, or treatment. Menstrual disorders may have different causes in different individuals. Always consult a qualified healthcare provider or gynecologist for personalized medical guidance.

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