Hereditary Haemochromatosis (HFE): Causes, Symptoms, Diagnosis & Treatment

By Sam
Hereditary Haemochromatosis (HFE): Causes, Symptoms, Diagnosis, and Treatment Complete article to Iron Overload Disorder | Symptoms, Genetics, Testing, and Management Hereditary Haemochromatosis (HFE) is one of the most common genetic disorders affecting iron metabolism in the human body. Despite its prevalence, it remains widely underdiagnosed due to its slow progression and non-specific early symptoms. This condition leads to excessive absorption and accumulation of iron in vital organs such as the liver, heart, pancreas, joints, and skin. Over time, this excess iron can cause serious and potentially life-threatening complications. In this comprehensive article, we will explore what Hereditary Haemochromatosis is, how it develops, its genetic basis, symptoms, diagnostic methods, treatment options, lifestyle modifications, and long-term outlook. This article is designed to be informative, easy to understand, and valuable for patients, caregivers, medical students, and hea...
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High red blood cell count

By Sam

 Causes

High red cell count can be caused by low oxygen levels, kidney disease or other problems.

Low oxygen level



Your body can increase the production of red blood cells to compensate for any conditions that lead to lower oxygen levels, including:
  • Heart disease (such as congenital heart disease in adults)
  • Heart failure
  • A condition at birth that reduces the oxygen-carrying capacity of red blood cells (hemoglobinopathy)
  • High altitude
  • COPD (chronic obstructive pulmonary disease) escalation - symptomatic deterioration
  • Pulmonary fibrosis (red and damaged lungs)
  • Other lung diseases
  • Sleep apnea
  • Nicotine dependence (smoking)
Drugs that improve performance
Certain drugs stimulate the production of red blood cells, including:
  • Anabolic steroids
  • Performing blood doping (transfusion)
  • Injection of the protein (erythropoietin) that improves red blood cell production

Increased concentration of red blood cells

  • Dehydration (When the plasma level is reduced, as it requires thirst, the number of red blood cells increases. This is because red blood cells are highly concentrated. The actual number of red blood cells remains the same.)

Kidney disease

Often, in some kidney cancer and sometimes after a kidney transplant, the kidneys can produce too much erythropoietin. This improves the production of red blood cells.

Excessive bone marrow transplantation

  • Polycythemia vera
  • Other myeloproliferative disorders

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